Ziprasidone and Hypokalemia

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Ziprasidone and hypokalemia: a case of 2 predisposing factors for QTc prolongation without development of torsades de pointes.

Sir: Although concerns about sudden cardiac arrhythmia death associated with the use of an antipsychotic drug actually predate the description of torsades de pointes, it is this fatal arrhythmia and its electrocardiographic (ECG) predictor (corrected QT [QTc] interval prolongation) that have become of increasing concern related to the use of antipsychotic medications during recent years. The fi...

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NDA 20-825 Approval Letter and Labeling Page 4 ATTACHMENT 1 Ziprasidone (Ziprasidone HCl) DESCRIPTION Ziprasidone is available as Ziprasidone Capsules (ziprasidone hydrochloride) for oral administration. Ziprasidone is an antipsychotic agent that is chemically unrelated to phenothiazine or butyrophenone

Ziprasidone Capsules contain a monohydrochloride, monohydrate salt of ziprasidone. Chemically, ziprasidone hydrochloride monohydrate is 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, monohydrate The empirical formula is C21H21ClN4OS · HCl · H2O and its molecular weight is 467.42. Ziprasidone hydrochloride monohydrate is a white to s...

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Hypokalemia and Hyperkalemia

A complete Works Cited list begins on page 15. Mention of commercial products does not indicate endorsement. Faculty Carol Whelan, APRN, has been working in nursing education since 2000. She received her Master’s degree in psychiatric/mental health nursing from St. Joseph College in West Hartford, Connecticut, and completed post-graduate nurse practitioner training at Yale University. Ms. Whela...

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Prolactin elevation with ziprasidone.

Ms. A had a history of bipolar disorder and developed postpartum psychosis after her first child was born. She responded to lithium and risperidone. After the delivery of a second child while taking lithium, she again required risperidone (1.5 mg/day) for mood instability and obsessive ruminations about harming her baby. She had trace cogwheeling but no other extrapyramidal symptoms. She did no...

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Ziprasidone-induced hypomania

Dear Editor, The literature mentions innumerable substances which may induce symptoms of mania and hypomania. Besides antidepressants, which are well described, we should highlight atypical antipsychotics, as they have been used as adjuvants in the treatment of affective disorders. Cases of mania and hypomania induced by risperidone and olanzapine have been observed; however, few and isolated r...

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ژورنال

عنوان ژورنال: The Primary Care Companion to The Journal of Clinical Psychiatry

سال: 2005

ISSN: 1523-5998

DOI: 10.4088/pcc.v07n0312